The cannabis plant produces around 100 cannabinoids. You probably know about THC and CBD, but others play a role in the effects a strain produces.
Cannabichromene (CBC) was discovered fifty years ago, but we’re just known starting to understand the therapeutic potential of this cannabinoid.
Let’s take a look at CBC and how it positively impacts the therapeutic potential of cannabis use.
What is Cannabichromene (CBC)?
Like CBD, CBC is non-psychoactive and promotes homeostasis (mind/body balance).
The acid form of CBC (CBCa) is derived from the same parent (I use the term loosely) as THCa and CBDa, which is Cannabigerol acid (CBGa).
CBC and Plant Synergy (The Entourage Effect)
Plant synergy is what makes the effects of cannabis effective. Cannabinoids like CBD, CBC, THC, and phytocompounds and terpenes work together to restore mind/body balance.
When it comes to recreational cannabis use, the effects might not be noticeable. However, the medical cannabis community is avidly investigating what role this cannabinoid plays in the Entourage Effect.
CBC enhances necessary chemicals like anandamide in the body and also decreases the degradation of other beneficial cannabinoids.
CBC is a team player and helps other phytocompounds like terpenes do their jobs.
The result? Potential therapeutic benefits like pain relief and happiness are increased.
We mentioned the acid form of CBGa is the starting form of the acid forms of CBCa, CBDa, and THCa.
When these acid forms are exposed to heat, they are converted and produce the benefits we are familiar with.
Cannabichromene acts similliar to cannabidiol.
CBC may appear in cannabis strains in lower doses than CBD, but recent research shows it is a promising cannabinoid with many therapeutic benefits.
Let’s take a look at a few medical ailments that may benefit from CBC.
CBC Potential Therapeutic Properties (Medical Benefits)
Antiinflammatory & Physical Pain
Cannabis is an effective treatment for aches and pains. One of the primary forms of inflammation is collagen-induced osteoarthritis.
CBC seems to be an effective pain blocker when it comes to this type of pain.
This study shows that when CBC and THC work together, their anti-inflammatory properties increase.
When it comes to acne, CBC acts similar to CBD and is an effective holistic treatment.
Most scientific research focuses on CBD, but this study shows that other cannabinoids like CBC “behave in a CBD-like manner.”
CBC calms inflammation and decreases sebum production in the skin, which are the two main contributing factors that create acne.
Cannabichromene is effective at enhancing neurogenesis ( the creation of brain cells).
This study shows that CBC can actively promote progenitor cells and positively affect the neural stem.
In English, this means that CBD promotes brain homeostasis (mind/body balance).
Astroglia are brain cells with many functions and are the key to a healthy head (brain). CBC helps transform cells into important neurons and astroglia.
Astroglial cells are essential when it comes to vital brain health. They help repair the brain, care for cells that make up the blood-brain barrier and provide nutrients to nerve tissues.
While research is still in its infancy, CBC is proving to have significant therapeutic potential on certain types of cancer.
This study focuses on a form of urine cancer, and the results show that CBC made up 85% and was the most active fraction. Meaning, it was the most prominent cannabinoid working alongside other cannabinoids like THC and CBD.
Our body creates its own cannabinoids, one of which is anandamide.
CBC is showing to actively work with this endocannabinoid, which promotes the reduction of specific cancer symptoms.
CBC helps anandamide stay in our bloodstream longer (this is a good thing). It’s too early to make any promises, but cannabigerol’s role in anti-cancer therapies seems quite promising.
The Entourage Effect is in full force when it comes to the potential therapeutic benefits of CBC in treating the symptoms of depression.
Working alongside other essential cannabinoids like CBD and THC, CBC promotes healthy functions and reduces sadness brought on by depression.
CBC: Final Thoughts
Cannabis research has a long way to go before making any guarantees about the effectiveness in treating medical conditions.
We have so much to learn, but the future is looking bright. What we do know is that cannabinoids like CBC show serious therapeutic potential.
As always, stay lifted!
Izzo, A. A., Capasso, R., Aviello, G., Borrelli, F., Romano, B., Piscitelli, F., ... & Di Marzo, V. (2012). Inhibitory effect of cannabichromene, a major non‐psychotropic cannabinoid extracted from Cannabis sativa, on inflammation‐induced hypermotility in mice. British journal of pharmacology, 166(4), 1444-1460.
De Zeeuw, R. A., Vree, T. B., Breimer, D. D., & Van Ginneken, C. A. M. (1973). Cannabivarichromene, a new cannabinoid with a propyl side chain in Cannabis. Experientia, 29(3), 260-261.
Pollastro, F., Caprioglio, D., Del Prete, D., Rogati, F., Minassi, A., Taglialatela-Scafati, O., ... & Appendino, G. (2018). Cannabichromene. Natural Product Communications, 13(9), 1934578X1801300922.
Wirth, P. W., Watson, E. S., ElSohly, M., Turner, C. E., & Murphy, J. C. (1980). Anti-inflammatory properties of cannabichromene. Life sciences, 26(23), 1991-1995.
Anis O, Vinayaka AC, Shalev N, et al. Cannabis-Derived Compounds Cannabichromene and Δ9-Tetrahydrocannabinol Interact and Exhibit Cytotoxic Activity against Urothelial Cell Carcinoma Correlated with Inhibition of Cell Migration and Cytoskeleton Organization. Molecules. 2021;26(2):465. Published 2021 Jan 17. doi:10.3390/molecules26020465
Shinjyo, N., & Di Marzo, V. (2013). The effect of cannabichromene on adult neural stem/progenitor cells. Neurochemistry international, 63(5), 432-437.
About the author: Heather Burton
Heather lives with her husband and two children in beautiful British Columbia. Her passion has always been to enhance the lives of others by helping them reach their business goals.
Content management is her specialty, and writing is what she does best. Working specifically in the cannabis market, Heather strives to help dispensaries, patients, doctors, manufacturers and recreational users by giving them the voice they need. When she is not writing, you can find her anywhere outdoors and away from the screen.